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IMSI - Intracytoplasmic Sperm Injection: the direct way

Intracytoplasmic Morphologically Selected-Sperm Injection (IMSI)

Using high-resolution microscopes, sperm cells are selected to be injected into an egg cell that shows little to no external abnormalities. This selection is usually not possible with the average 200x magnification, as abnormal microstructures in the sperm will not yet be recognisable. With IMSI, the sperm are screened with 400-600x magnification without real time staining. However, the influence of sperm micromorphology on the outcome of fertility treatment is contested. Therefore, a general recommendation cannot be made for IMSI.